Why the study?
Does combination therapy of bosentan and sildenafil provide a safe and effective alternative to prostacyclin infusion in childhood pulmonary arterial hypertension?
Does combination therapy of bosentan and sildenafil provide a safe and effective alternative to prostacyclin infusion in childhood pulmonary arterial hypertension?
Combination therapy with bosentan and sildenafil may be a safe and effective alternative to prostacyclin infusion in pediatric patients with pulmonary arterial hypertension.
We report a case of a seven-yr-old girl with a PAH treated with continuation therapy of bosentan and sildenafil. The combination therapy revealed safety and efficacy in long-term follow up.
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Brancaccio et al. (2006) studied this question.
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