Hepatitis B Virus DNA in Fulminant Hepatitis B

Brief Reports1 October 1986Hepatitis B Virus DNA in Fulminant Hepatitis BKEVIN M. DE COCK, M.D., M.R.C.P., D.T.M.&H., SUGANTHA GOVINDARAJAN, M.D., BOONTAR VALINLUCK, B.S., ALLAN G. REDEKER, M.D.KEVIN M. DE COCK, M.D., M.R.C.P., D.T.M.&H.Search for more papers by this author, SUGANTHA GOVINDARAJAN, M.D.Search for more papers by this author, BOONTAR VALINLUCK, B.S.Search for more papers by this author, ALLAN G. REDEKER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-4-546 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients with fulminant hepatitis B have hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) detected for shorter periods than do patients with nonfulminant infections, and they show early and enhanced production of antibodies to HBsAg, HBeAg, and hepatitis B core antigen (HBcAg) (1-3). These observations have been interpreted as evidence that fulminant hepatitis results from the host's immunologic response to the infection rather than from hepatitis B virus replication.Modern techniques for detecting hepatitis B virus DNA in serum provide the most sensitive method available for showing active viral replication (4-6). We examined hepatitis B virus DNA...References1. TREPOROBERTMOTINTREPOSEBASTIANPRINCE CDJDMA. Hepatitis B antigen (HBsAg) and/or antibodies (anti-HBs and anti-HBc) in fulminant hepatitis: pathogenetic and prognostic significance. Gut. 1976;17:10-3. CrossrefMedlineGoogle Scholar2. WOOLFEL SHEIKCULLENS INH. Enhanced HBsAg production in pathogenesis of fulminant viral hepatitis type B. Br Med J 1976;2:669-71. CrossrefMedlineGoogle Scholar3. GIMSONTEDDERWHITEEDDLESTONWILLIAMS ARYAR. Serological markers in fulminant hepatitis B. Gut. 1983;24:615-7. CrossrefMedlineGoogle Scholar4. BERNINGERHAMMERHOYERGERIN MMBJ. An assay for the detection of the DNA genome of hepatitis B virus in serum. J Med Virol. 1982;9:57-68. CrossrefMedlineGoogle Scholar5. WELLERFOWLERMONJARDINOTHOMAS IMJH. The detection of HBV-DNA in serum by molecular hybridisation: a more sensitive method for the detection of complete HBV particles. J Med Virol. 1982;9:273-80. CrossrefMedlineGoogle Scholar6. SCOTTOHADCHOUELHERYYVARTTIOLLAISBRECHOT JMCJPC. Detection of hepatitis B virus DNA in serum by a simple spot hybridization technique: comparison with results of other viral markers. Hepatology 1983;3:279-84. CrossrefMedlineGoogle Scholar7. LEMONGATESSIMMSBANCROFT SNTW. IgM antibody to hepatitis B core antigen as a diagnostic parameter of acute infection with hepatitis B virus. J Infect Dis. 1981;143:803-9. CrossrefMedlineGoogle Scholar8. GOVINDARAJANCHINREDEKERPETERS SKAR. Fulminant B viral hepatitis: role of delta agent. Gastroenterology. 1984;86:1417-20. CrossrefMedlineGoogle Scholar9. BRECHOTBERNUAUTHIERS CJV. Multiplication of hepatitis B virus in fulminant hepatitis B. Br Med J. 1984;288:270-1. CrossrefMedlineGoogle Scholar10. FROMMELALLAINCOUROUCE DJA. Long-lasting abatement of HBsAg synthesis induced by acute delta infection [Letter]. Lancet. 1983;1:656-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Southern California Liver Unit Rancho Los Amigos Medical Center Downey, California. 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Akriviadis, MD, Sugantha Govindarajan, MD, Boontar Valinluck, MS, Allan G. Redeker, MDDoes tumor necrosis factor play a role in the pathogenesis of fulminant hepatitis?Hepatitis B virus DNA in serum. Applied molecular biology in the evaluation of hepatitis B infectionAntibodies to translation products of the pre-S1 and pre-S2 regions of the envelope gene of hepatitis B virus in fulminant hepatitis BHepatitis B Serology—Help in Interpretation 1 October 1986Volume 105, Issue 4Page: 546-547KeywordsAntigensDNAHepatitis BHepatitis B surface antigenHepatitis B virusHepatitis virusesInfectious hepatitisViral diseasesViral pathogensViral replication Issue Published: 1 October 1986 PDF DownloadLoading ...