Ferrokinetic studies were performed in 14 male patients with cancer who were given one of 5 different chemotherapeutic agents (methotrexate, fluorouracil, actinomycin D, hydroxyurea, galactoflavin). These drugs, which are capable of suppressing erythropoiesis via different mechanisms, produced similar alterations in ferrokinetics. The characteristic effects were a prolonged plasma disappearance of radioiron, a decreased uptake of radioiron by erythrocytes, a high uptake by the liver and a low uptake by the sacral marrow. Radioiron incorporated by the liver was released very slowly, which indicated that storage iron had been labeled. The changes observed with these drugs were similar to effects produced in previous studies with nitrogen mustard.
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Alfrey et al. (1966) studied this question.
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