October 31, 2011Circulation JournalOpen Access

Medetomidine, an .ALPHA.2-Adrenergic Agonist, Activates Cardiac Vagal Nerve Through Modulation of Baroreflex Control

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Why the study?

Does intravenous medetomidine increase acetylcholine release from cardiac vagal nerve endings in anesthetized rabbits?

Structured PICO

Does intravenous medetomidine increase acetylcholine release from cardiac vagal nerve endings in anesthetized rabbits?

Population

Anesthetized rabbits with a microdialysis probe implanted into the right atrial wall near the sinoatrial node

Intervention

Intravenous medetomidine (10 and 100 µg/kg), alone or combined with phenylephrine

Comparator

Baseline levels

Outcome

Dialysate norepinephrine (NE) and acetylcholine (ACh) concentrations from cardiac nerve endingssurrogate

Medetomidine increases acetylcholine release from cardiac vagal nerve endings and augments baroreflex control of vagal nerve activity in a rabbit model.

Discussion

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Implication

High-dose medetomidine may enhance cardiac vagal ACh release in rabbits; leaves open translation to human autonomic control.

Cite This Study

Shimizu et al. (2011) studied this question.

synapsesocial.com/papers/6a7cd1eca0b19b72d9f46e3e https://doi.org/10.1253/circj.cj-11-0574

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Medetomidine, an .ALPHA.2-Adrenergic Agonist, Activates Cardiac Vagal Nerve Through Modulation of Baroreflex Control

Structured PICO

Discussion

Implication

Cite This Study

Medetomidine, an .ALPHA.2-Adrenergic Agonist, Activates Cardiac Vagal Nerve Through Modulation of Baroreflex Control

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider