We compare molecular gas traced by 12 CO (2–1) maps from the HERACLES survey, with tracers of the recent star formation rate (SFR) across 30 nearby disk galaxies. We demonstrate a first-order linear correspondence between Σ mol and Σ SFR but also find important second-order systematic variations in the apparent molecular gas depletion time, . At the 1 kpc common resolution of HERACLES, CO emission correlates closely with many tracers of the recent SFR. Weighting each line of sight equally, using a fixed α CO equivalent to the Milky Way value, our data yield a molecular gas depletion time, Gyr with 0.3 dex 1σ scatter, in very good agreement with recent literature data. We apply a forward-modeling approach to constrain the power-law index, N , that relates the SFR surface density and the molecular gas surface density, . We find N = 1 ± 0.15 for our full data set with some scatter from galaxy to galaxy. This also agrees with recent work, but we caution that a power-law treatment oversimplifies the topic given that we observe correlations between and other local and global quantities. The strongest of these are a decreased in low-mass, low-metallicity galaxies and a correlation of the kpc-scale with dust-to-gas ratio, D/G. These correlations can be explained by a CO-to-H 2 conversion factor (α CO ) that depends on dust shielding, and thus D/G, in the theoretically expected way. This is not a unique interpretation, but external evidence of conversion factor variations makes this the most conservative explanation of the strongest observed trends. After applying a D/G-dependent α CO , some weak correlations between and local conditions persist. In particular, we observe lower and enhanced CO excitation associated with nuclear gas concentrations in a subset of our targets. These appear to reflect real enhancements in the rate of star formation per unit gas, and although the distribution of τ dep does not appear bimodal in galaxy centers, τ dep does appear multivalued at fixed Σ H2 , supporting the idea of "disk" and "starburst" modes driven by other environmental parameters.
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