A highly simplified synthesis of a tetrasaccharide was possible by a repeated coupling/capture–release cycle. In the first cycle, a glycosyl acceptor (1) bound to a soluble polymer reacted with a glycosyl donor (2) having a chloroacetyl group as a temporary protecting group. Solid-phase capture by a resin-bound thiol group (in 3) was followed by Fmoc removal, which released the polymer-bound disaccharide 4 into the solution phase. Fmoc=9-fluorenylmethoxycarbonyl.
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Ando et al. (2001) studied this question.
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