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January 29, 2021ESC Heart FailureOpen Access

Endothelial NADPH Oxidase 4 Protects Against Angiotensin II-Induced Cardiac Fibrosis and Inflammation

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Why the study?

Endothelial activation and inflammatory infiltration contribute to renin-angiotensin-induced cardiac fibrosis, but the specific effects of endothelial cell Nox4 on cardiac fibrosis remain unknown.

Does endothelial Nox4 overexpression prevent Angiotensin II-induced cardiac fibrosis in mice?

Population

Transgenic mice overexpressing endothelial-restricted Nox4 and wild-type littermates

Comparison

Transgenic mice vs wild-type controls subjected to chronic AngII infusion

Design

Animal experimental study

Follow-up

14 days

Authors

MWMinshu WangCMColin E. MurdochABAlison C. Brewer

Discussion

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Member takes

Overview

Endothelial Nox4 modulation merits further mechanistic study in fibrosis models; leaves open any clinical relevance in human heart failure.

Structured PICO

Does endothelial Nox4 overexpression prevent Angiotensin II-induced cardiac fibrosis in mice?

P
Population
Transgenic (TG) mice overexpressing endothelial-restricted Nox4 and wild-type (WT) littermates
I
Intervention
Chronic Angiotensin II (AngII) infusion (1.1 mg/kg/day) for 14 days
C
Comparator
Wild-type (WT) mice receiving AngII infusion or saline
O
Outcome
Interstitial cardiac fibrosissurrogate

Endothelial Nox4 overexpression protects against Angiotensin II-induced cardiac fibrosis by inhibiting endothelial cell activation and inflammatory cell recruitment.

Cite This Study

Wang et al. (2021) studied this question.

synapsesocial.com/papers/6a7cde399092f18ef00eafeehttps://doi.org/10.1002/ehf2.13228
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Also Consider

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  1. 1NADPH Oxidase-4 Driven Cardiac Macrophage Polarization Protects Against Myocardial Infarction–Induced Remodeling2017 · 48 citations
  2. 2NAD(P)H Oxidase 4 Mediates Transforming Growth Factor-β1–Induced Differentiation of Cardiac Fibroblasts Into Myofibroblasts2005 · 788 citations
  3. 3NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth2013 · 78 citations
  4. 4Requirement of Rac1 in the development of cardiac hypertrophy2006 · 276 citations
  5. 5Cardiac Remodeling: Endothelial Cells Have More to Say Than Just NO2018 · 161 citations