Guided tissue regeneration combined with a deproteinized bovine bone mineral (Bio‐Oss®) in the treatment of intrabony periodontal defects: 6‐year results from a randomized‐controlled clinical trial

Stavropoulos A, Karring T. Guided tissue regeneration combined with a deproteinized bovine bone mineral (Bio‐Oss ® ) in the treatment of intrabony periodontal defects: 6‐year results from a randomized‐controlled clinical trial. J Clin Periodontol 2010; 37: 200–210. doi: 10.1111/j.1600‐051X.2009.01520.x. Abstract Aim: To present the 6‐year results of a randomized‐controlled clinical trial evaluating guided tissue regeneration (GTR) combined with or without deproteinized bovine bone mineral (DBBM) in intrabony defects. Material & Methods: In each of 45 patients, one defect was treated with GTR combined with DBBM hydrated in saline (DBBM−) or gentamicin sulphate (DBBM+) or with GTR alone. Clinical parameters were recorded pre‐surgery, at 1 and 6 years postsurgery. Results: Thirty‐six patients/33 teeth were available for the 6‐year control. Statistically significant clinical improvements were observed for all treatments. Clinical attachment level (CAL) gain averaged 2.5 mm (DBBM−), 4.1 mm (DBBM+), and 3.0 mm (GTR) at 1 year postsurgery, and remained stable over 5 additional years (2.3, 4.1, and 2.7 mm, respectively). Treatment did not appear to influence residual probing depths (PDs) or CAL gains at 6 years postsurgery, or the extent of PD and CAL change from 1 to 6 years, and did not associate with sites losing CAL during follow‐up. No association of grafting with sites showing CAL gain 4 mm at the 1‐ or 6‐year control was observed. Conclusion: The improvements in periodontal conditions obtained after GTR treatment with or without the adjunct use of DBBM can be preserved on a long‐term basis.