November 1, 1999NeoplasiaOpen Access

HSV-1-Based Vectors for Gene Therapy of Neurological Diseases and Brain Tumors: Part II. Vector Systems and Applications

View Full Paper

Ask AI

Bookmark

Population

Patients or experimental models with neurological diseases affecting the central nervous system or…

Design

Review

Authors

XBXandra O. BreakefieldPennington Biomedical Research Center CFCornel FraefelUniversity of Zurich

Discussion

Member takes

Implication

HSV-1 vectors merit expanded preclinical optimization for CNS gene therapy; leaves open clinical translation pending safety and efficacy trials.

Structured PICO

Population

Patients or experimental models with neurological diseases affecting the central nervous system (CNS) or peripheral nervous system (PNS), such as Parkinson's disease, malignant gliomas, neurodegenerative disorders, or chronic pain

Intervention

HSV-1-based vectors (including replication-conditional HSV-1 vectors and helper virus-free HSV/AAV hybrid amplicon vectors) for gene therapy

HSV-1-derived vectors represent a promising approach for gene therapy in neurological diseases and brain tumors, with ongoing research focusing on targeted and transcriptionally regulatable transgene expression.

Cite This Study

Breakefield et al. (1999) studied this question.

synapsesocial.com/papers/6a7cf2d1cc8444f0202fa7f1 https://doi.org/10.1038/sj.neo.7900056

View Full Paper

Ask AI

Bookmark

Implication

HSV-1 vectors merit expanded preclinical optimization for CNS gene therapy; leaves open clinical translation pending safety and efficacy trials.

HSV-1-Based Vectors for Gene Therapy of Neurological Diseases and Brain Tumors: Part II. Vector Systems and Applications

Discussion

Member takes

Implication

Structured PICO

Cite This Study

HSV-1-Based Vectors for Gene Therapy of Neurological Diseases and Brain Tumors: Part II. Vector Systems and Applications

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider