Antibiotic resistance and biofilm formation ability among coagulase-negative staphylococci in healthy individuals from Portugal

Rogers, K. L., Fey, P. D. & Rupp, M. E. Coagulase-negative staphylococcal infections. Infect. Dis. Clin. North Am. 23 , 73–98 (2009). Article PubMed Google Scholar Ziebuhr, W. et al . Nosocomial infections by Staphylococcus epidermidis : how a commensal bacterium turns into a pathogen. Int. J. Antimicrob. Agents 28 (Suppl 1), S14–S20 (2006). Article CAS PubMed Google Scholar Cerca, N. et al . Comparative assessment of antibiotic susceptibility of coagulase-negative staphylococci in biofilm versus planktonic culture as assessed by bacterial enumeration or rapid XTT colorimetry. J. Antimicrob. Chemother. 56 , 331–336 (2005). Article CAS PubMed Google Scholar Otto, M. Staphylococcus epidermidis —the 'accidental' pathogen. Nat. Rev. Microbiol. 7 , 555–567 (2009). Article CAS PubMed PubMed Central Google Scholar Mellmann, A. et al . Sequencing and staphylococci identification. Emerg. Infect. Dis. 12 , 333–336 (2006). Article CAS PubMed PubMed Central Google Scholar European Committee for Antimicrobial Susceptibility Testing of the European Society of Clinical, M. & Infectious, D. Determination of minimum inhibitory concentrations (MICs) of antibacterial agents by broth dilution. Clin. Microbiol. Infect. 9 , ix–xv (2003). Article Google Scholar Stepanovic, S., Vukovic, D., Dakic, I., Savic, B. & Svabic-Vlahovic, M. A modified microtiter-plate test for quantification of staphylococcal biofilm formation. J. Microbiol. Methods 40 , 175–179 (2000). Article CAS PubMed Google Scholar Cerca, N., Pier, G. B., Vilanova, M., Oliveira, R. & Azeredo, J. Influence of batch or fed-batch growth on Staphylococcus epidermidis biofilm formation. Lett. Appl. Microbiol. 39 , 420–424 (2004). Article CAS PubMed PubMed Central Google Scholar Widerstrom, M., Wistrom, J., Ek, E., Edebro, H. & Monsen, T. Near absence of methicillin-resistance and pronounced genetic diversity among Staphylococcus epidermidis isolated from healthy persons in northern Sweden. APMIS 119 , 505–512 (2011). Article PubMed Google Scholar Piette, A. & Verschraegen, G. Role of coagulase-negative staphylococci in human disease. Vet. Microbiol. 134 , 45–54 (2009). Article CAS PubMed Google Scholar Steinke, D. & Davey, P. Association between antibiotic resistance and community prescribing: a critical review of bias and confounding in published studies. Clin. Infect. Dis. 33 (Suppl 3), S193–S205 (2001). Article PubMed Google Scholar Martinez, J. L. Environmental pollution by antibiotics and by antibiotic resistance determinants. Environ. Pollut. 157 , 2893–2902 (2009). Article CAS PubMed Google Scholar European Centre for Disease Prevention and Control.. Surveillance of Antimicrobial Consumption in Europe, 2010. European Centre for Disease Prevention and Control Stockholm,, (2013). Cove, J. H., Eady, E. A. & Cunliffe, W. J. Skin carriage of antibiotic-resistant coagulase-negative staphylococci in untreated subjects. J. Antimicrob. Chemother. 25 , 459–469 (1990). Article CAS PubMed Google Scholar de Araujo, G. L. et al . Commensal isolates of methicillin-resistant Staphylococcus epidermidis are also well equipped to produce biofilm on polystyrene surfaces. J. Antimicrob. Chemother. 57 , 855–864 (2006). Article PubMed Google Scholar Hellmark, B., Soderquist, B., Unemo, M. & Nilsdotter-Augustinsson, A. Comparison of Staphylococcus epidermidis isolated from prosthetic joint infections and commensal isolates in regard to antibiotic susceptibility, agr type, biofilm production, and epidemiology. Int. J. Med. Microbiol. 303 , 32–39 (2013). Article PubMed Google Scholar Agarwal, A. & Jain, A. Association between drug resistance & production of biofilm in staphylococci. Indian J. Med. Res. 135 , 562–564 (2012). PubMed PubMed Central Google Scholar Download references