A trimodal magnetic navigation-enhanced nanoplatform for spatiotemporally controlled chemo-photodynamic synergistic cancer therapy

evaluation in 4T1 tumor-bearing mice showed that magnetic navigation significantly enhanced tumor accumulation of NPs, leading to 73% tumor growth inhibition through synergistic chemo-PDT effects. The combination of magnetic targeting and dual therapeutic modalities resulted in superior antitumor efficacy compared to individual treatments, with minimal systemic toxicity. These findings highlight the potential of this multifunctional nanoplatform as a precise and effective strategy for solid tumor therapy, offering improved targeting and reduced off-target effects compared to conventional treatments.