Why the study?
Does statin treatment improve early outcomes in patients with acute coronary syndromes?
Does statin treatment improve early outcomes in patients with acute coronary syndromes?
Statin therapy, whether chronic or initiated upon admission, is associated with reduced major cardiac events and in-hospital mortality in patients presenting with acute coronary syndromes.
Statin use was associated with fewer early events in ACS; leaves open whether admission initiation improves outcomes in randomized trials.
OBJECTIVES: The role of statin use in the treatment of acute coronary syndromes (ACS) is not clear. The aim of our study was to evaluate the role of statins in ACS. METHODS: Using data from the Acute Myocardial Infarction in Switzerland (AMIS Plus) Project, we compared the effects of chronic statin use, statin therapy after admission and no statin therapy on presentation mode and outcomes in ACS. RESULTS: Available data from the period 2001-2006 including 11,603 patients were analyzed. Major cardiac event rates and in-hospital mortality were more common in statin-naive patients compared to patients who received statins. CONCLUSIONS: Our results support the importance of statin treatment in ACS. Chronic statin therapy seems to alter the initial presentation of ACS but it is questionable whether it provides an additional effect on early outcomes compared to the establishment of statin therapy after admission in statin-naive patients.
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Cuculi et al. (2007) studied this question.
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