Why the study?
The study tested peptidylarginine deiminase 2 (PAD2) as a novel regulator of diastolic dysfunction in the aging female heart.
Does loss of PAD2 cause diastolic dysfunction in aging female mice?
Does loss of PAD2 cause diastolic dysfunction in aging female mice?
Loss of PAD2 causes diastolic dysfunction in aging female mice independent of estrogen, highlighting a potential novel mechanism for diastolic dysfunction in aging women.
We tested peptidylarginine deiminase 2 (PAD2) as a novel regulator of diastolic dysfunction in the aging female heart. We found that PAD2 expression declines with age in the female heart and loss of PAD2 causes diastolic dysfunction. However, unlike in female reproductive tissue, PAD2 in the heart is not regulated by estrogen. Given the large burden of diastolic dysfunction in aging women, future work to understand the regulation of PAD2 and diastolic dysfunction is warranted.
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Shorthill et al. (2025) studied this question.
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