Studies of the comparative effects of a semi‐synthetic diet containing supplements of corn oil, no fat, linolenate or trans,trans ‐linoleate on blood coagulation parameters are reported. In spite of large differences in fatty acid composition of the tissue lipids of the different groups, the only diets that appeared to produce abnormal hematologic and hemostatic properties were those containing trans,trans ‐linoleate. These groups of animals showed significant differences from a control group of animals fed Purina rat chow in platelet and fibrinogen concentration, and values for hematocrit and prothrombin time. A positive fibrinolysin test was also obtained in about 50% of the animals fed trans,trans ‐linoleate.
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Raccuglia et al. (1970) studied this question.
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