Population
Valvular interstitial cells (VICs)
Comparison
Heparin oligosaccharides of different sizes vs Other saccharides and full-length heparin
Design
Preclinical
Authors
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Shorter heparin fragments may promote VIC activation in vitro; hypothesis-generating for chain-length effects on valve fibrosis.
Heparin chain length influences valvular interstitial cell activation, with octasaccharides and decasaccharides promoting α-SMA expression unlike full-length heparin.
Pedrón et al. (2010) studied this question.
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