What question did this study set out to answer?

To determine whether leukotrienes C4, D4, and E4 are present in the airways of neonates diagnosed with persistent pulmonary hypertension.

July 14, 1983New England Journal of Medicine

Leukotriene C₄and D₄in Neonates with Hypoxemia and Pulmonary Hypertension

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Authors

KSKurt R. StenmarkPediatric Cardiology SJSimon JamesUniversity of Cambridge NVNorbert F. VoelkelVascular Medicine

Discussion

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Implication

Case-control study reveals airway leukotrienes C4 and D4 in neonates with persistent pulmonary hypertension, suggesting these inflammatory mediators contribute to newborn hypoxemia.

Key Points

To determine whether leukotrienes C4, D4, and E4 are present in the airways of neonates diagnosed with persistent pulmonary hypertension.
Analyzed lung lavage fluids from 5 newborns with clinically diagnosed persistent pulmonary hypertension who required mechanical ventilatory assistance.
Compared findings against a control group of 14 mechanically ventilated infants without persistent pulmonary hypertension.
Leukotriene C4 and leukotriene D4 were detected in the lung lavage fluids of all 5 (100%) newborns diagnosed with persistent pulmonary hypertension.
Leukotrienes were undetectable in the lung lavage fluids of all 14 control infants requiring ventilatory assistance.

Cite This Study

Stenmark et al. (1983) studied this question.

synapsesocial.com/papers/6a7d135f274d9b3610aa070f https://doi.org/10.1056/nejm198307143090204

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Implication

Case-control study reveals airway leukotrienes C4 and D4 in neonates with persistent pulmonary hypertension, suggesting these inflammatory mediators contribute to newborn hypoxemia.

Leukotriene C₄and D₄in Neonates with Hypoxemia and Pulmonary Hypertension

Discussion

Member takes

Implication

Key Points

Cite This Study

Leukotriene C₄and D₄in Neonates with Hypoxemia and Pulmonary Hypertension

Discussion

Member takes

Implication

Key Points

Cite This Study

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