Why the study?
Does celiac-superior mesenteric ganglionectomy or vagotomy suppress the sympathoadrenal response to insulin-induced hypoglycemia in male Wistar rats?
Does celiac-superior mesenteric ganglionectomy or vagotomy suppress the sympathoadrenal response to insulin-induced hypoglycemia in male Wistar rats?
Celiac-superior mesenteric ganglionectomy, but not vagotomy, suppresses the sympathoadrenal response to hypoglycemia, suggesting hypoglycemic detection at the portal vein is mediated by spinal rather than vagal afferents.
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Should not inform hypoglycemia management in patients; leaves open whether spinal afferents mediate portal glucose sensing in humans.
Fujita et al. (2005) studied this question.
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