June 7, 2006Cardiovascular ResearchOpen Access

Microtubule-associated protein-4 (MAP-4) inhibits microtubule-dependent distribution of mRNA in isolated neonatal cardiocytes

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Population

Cultured neonatal rat cardiocytes

Comparison

Adenoviral microtubule-associated protein-4… vs Undecorated microtubules (baseline/control)

Design

Preclinical

Authors

DSDimitri ScholzUniversity College Dublin PMPaul J. McDermottUniversity of East Anglia MGMaria N. GarnovskayaEnvironmental Protection Agency

Discussion

Member takes

Implication

Hypothesis-generating for MAP-4 regulation of intracellular transport in cardiomyocytes; leaves open any relevance to human cardiac disease or therapy.

Structured PICO

Population

Cultured neonatal rat cardiocytes

Intervention

Adenoviral microtubule-associated protein-4 (MAP-4) decoration of microtubules

Comparator

Undecorated microtubules (baseline/control)

Outcome

Velocity of microtubular transport of ribonucleoprotein particles and microtubular elongation speedsurrogate

This study demonstrates for the first time the presence of ribonucleoprotein particles in cardiocytes, their microtubular-related movement, and its specific inhibition by MAP-4.

Cite This Study

Scholz et al. (2006) studied this question.

synapsesocial.com/papers/6a7d1687f71d7d96a037cab8 https://doi.org/10.1016/j.cardiores.2006.04.001

View Full Paper

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Implication

Hypothesis-generating for MAP-4 regulation of intracellular transport in cardiomyocytes; leaves open any relevance to human cardiac disease or therapy.

Microtubule-associated protein-4 (MAP-4) inhibits microtubule-dependent distribution of mRNA in isolated neonatal cardiocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Microtubule-associated protein-4 (MAP-4) inhibits microtubule-dependent distribution of mRNA in isolated neonatal cardiocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider