Management of women at high risk of breast cancer

#### Summary points Breast cancer is the commonest malignancy diagnosed in women worldwide and accounts for over 30% of all cancers diagnosed in women in the United Kingdom.1 The average lifetime risk of developing breast cancer for women in the United Kingdom and United States is estimated to be 12%,1 although this may be an overestimate, as it is not clear what age this assumes a woman lives to and whether full adjustment has been made for those who die young from other causes. It is also unclear whether multiple breast cancers in a single woman are counted as several women with breast cancer. #### Sources and selection criteria We searched PubMed using search terms such as “breast cancer risk” and “hereditary breast cancer.” Studies included were those written in English, and included case-control studies, randomised control trials, and meta-analyses. We also consulted relevant national and international guidelines, including those of the National Institute for Health and Care Excellence, and we were part of the NICE Guideline Development Group where all relevant evidence was …