From an analysis of oxygen consumption rates, cells tested in vitro showed a partial but reversible inhibition in oxidative activity during treatment with NaNO/sub 2/. Morphological studies of living cells with phase contrast microscopy and of fixed material with the electron microscope revealed that the alveolar wall cell showed changes in the shape of the nucleus and the ultrastructure of the mitochondria during NO/sub 2/ treatment. These changes may offer the opportunity to describe and quantitate the biological effects of NO/sub 2/ and, possibly, of other air pollutants.
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Rounds et al. (1965) studied this question.
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