Acidity of a secondary ammonium group in a rotaxane system with a crown ether was unusually lowered. N-Acylation of the ammonium group by acid anhydrides or chlorides proceeded slowly in the presence of excess tertiary amine to give the N-acylated rotaxanes without salt structure.
No takes yet. Share an insight, caveat, or question.
Kihara et al. (2000) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: