Key result
Mesenchymal stem cells harbor HBV and mediate viral transmission into injured myocardium after infarction.
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UNLABELLED: We have previously showed that endothelial progenitor cells (EPCs) through uptake of hepatitis B virus (HBV) may play a critical role in mediating extrahepatic HBV diseases. However, it remains to be elucidated whether mesenchymal stem cells (MSCs) are capable of mediating HBV trans-infection into extrahepatic tissues. METHODS AND RESULTS: In this study, we showed that HBV antigens, HBV DNA and the viral particles were detected in MSCs after 3 days virus challenge. Neither HBV covalently closed circular DNA nor pregenomic RNA were detected in MSCs. Intravenously transplantation of HBV-exposed MSCs into myocardial infarction mouse model resulted in incorporation of HBV into injured heart and other damaged tissues. CONCLUSION: These results indicate that MSCs could serve as an additional extrahepatic virus reservoir, which may play a role at least in part in mediating HBV trans-infection into the injured tissues through the process of MSCs recruitment.
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Rong et al. (2008) studied Myocardial infarction and hepatitis B virus infection (mouse model). Intravenous transplantation of HBV-exposed mesenchymal stem cells was evaluated on Detection of HBV in MSCs and incorporation into injured heart and damaged tissues. Mesenchymal stem cells harbored HBV antigens, DNA, and viral particles after 3 days of challenge and mediated HBV incorporation into injured heart tissues in a myocardial infarction mouse model.
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