Mechanistic insights into the acetyl-CoA recognition by SLC33A1

Acetyl-coenzyme A (acetyl-CoA) is a pivotal metabolic intermediate that plays dual roles: it is both a product of numerous catabolic reactions and a precursor for a multitude of anabolic processes. In addition to these metabolic functions, acetyl-CoA acts as a donor for the acetylation modification of various proteins and glycolipids, which is crucial for regulating their activity and function 1 . Acetyl-CoA is widely present throughout various cellular compartments, such as the cytoplasm, nucleus, mitochondria, endoplasmic reticulum (ER), and peroxisomes. Maintaining the balance of acetyl-CoA in these organelles is vital for cellular metabolism and protein homeostasis 1 , 2 .