Genetic variants of ADAMTS7 confer risk for ischaemic stroke in the Chinese population

Figures

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  Figure 1. The linkage pattern of polymorphisms in ADAMTS7 gene. The shade of the diamonds represents the pairwise r2 between the two SNPs as defined by the top left and top right sides of the diamond. Shading represents the magnitude of the pairwise r2, with red shades reflecting high r2 (>0.80) and white shades reflecting low r2.

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  Figure 2. Mean values ± SD of relative ADAMTS7 mRNA in PBMCs from IS patients (IS, n = 87) and healthy subjects (controls, n = 50). the blank box and the black box represent the relative expressions of adamts7 in IS patients and controls, respectively, and the median is indicated by a bar across the box. p=0.63 when comparing relative adamts7 mRNA levels between IS patients and controls. mean values ± sd of adamts7 mRNA in pbmcs from IS patients and healthy subjects stratified according to the genotypes and alleles of rs3825807 (B) (*p = 0.025), rs11634042 (C) (*p = 0.045), rs4380028 (D) and rs7173743 (E), respectively. an asterisk indicates p < 0.05.

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  Figure 3. CIMT mean values ± SD of IS patients (n = 264) stratified according to the genotypes and alleles of rs3825807. (A), rs11634042 (B), rs4380028 (C) and rs7173743 (D), respectively.