The effect of 25-hydroxycholecalciferol (25-OH-D3) on tibial dyschondroplasia (TD) incidence was evaluated by a factorial experiment of two broiler lines and three diets. Birds from lines with high (HTD) and a low (LTD) incidence of TD were fed three diets (69 μg/kg basal level of vitamin D3 plus 25-OH-D3 at 0, 69, and 345 μg/kg finished feed, respectively). Supplemented 25-OH-D3 decreased TD incidence in LTD line birds, but not in HTD line birds. The relationship between amount of supplementary 25-OH-D3 and reduction of TD incidence was largely linear in LTD line males and greatly quadratic in LTD line females. Each increase of 10 μg 25-OH-D3/kg feed, up to 70 μg/kg, is predicted to decrease TD incidence by about 1 and 2% in LTD line female and male birds, respectively. The magnitude by which 25-OH-D3 supplementation can decrease TD incidence might be affected by age and genetic background of broiler chicks.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (1997) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: