Studies on the Mechanism of Action of Metaraminol (Aramine)

Article1 September 1963Studies on the Mechanism of Action of Metaraminol (Aramine)DONALD C. HARRISON, M.D., CHARLES A. CHIDSEY, M.D., EUGENE BRAUNWALD, M.D., F.A.C.P.DONALD C. HARRISON, M.D., CHARLES A. CHIDSEY, M.D., EUGENE BRAUNWALD, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-3-297 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical effectiveness of metaraminol (Aramine), a widely used sympathomimetic agent, has been well documented (1-4). However, the mechanism of its action on the heart and circulatory system is not clear. Although its duration of action is longer, many of the hemodynamic effects of metaraminol are identical to those produced by the sympathetic neurotransmitter, norepinephrine (5, 6). Since it has been shown previously that a number of aromatic vasoactive amines act primarily by releasing endogenous norepinephrine stores (7-9), it was considered that metaraminol may have a similar mechanism of action. This was further suggested by the clinical observation that after...References1. STECHELFISHMANSCHWARTZTURKOWITZMADONIAFANKHAUSER GHSIGHPFA: The use of aramine in clinical shock. Circulation 8: 834, 1956. CrossrefGoogle Scholar2. MILLSVOUDOUKISMOYERHEIDER LCIJJHC: Treatment of shock with sympatheticomimetic drugs. Arch. Intern. Med. (Chicago) 106: 132, 1961. Google Scholar3. . Use of metaraminol bitartrate as a vasopressor agent. JAMA 163: 1482, 1957. MedlineGoogle Scholar4. WEIL MH: Clinical studies on vasopressor agents: Metaraminol (Aramine); observations on its use in shock. Amer. J. Med. Sci. 230: 357, 1955. CrossrefMedlineGoogle Scholar5. SARNOFFCASEBERGLUNDSARNOFF SJRBELC: Ventricular function, V. 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HARRISONCHIDSEYBRAUNWALD DCCAE: Circulatory responses to cardioaccelerator nerve stimulation after the induction of tyramine tachyphylaxis. Proc. Soc. Exp. Biol. Med. 112: 37, 1963. CrossrefMedlineGoogle Scholar24. BURNRAND JHMJ: Fall of blood pressure after a norepinephrine infusion and its treatment by pressor agents. Brit. Med. J. 1: 294, 1959. CrossrefGoogle Scholar25. UDENFRIENDZALTZMAN-NIERENBERG SP: On the mechanism of the norepinephrine release produced by α-methyl-meta tyrosine. J. Pharmacol. Exp. Ther. 138: 194, 1962. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DONALD C. HARRISON, M.D.; CHARLES A. CHIDSEY, M.D.; EUGENE BRAUNWALD, M.D., F.A.C.P.Affiliations: Bethesda, MarylandFrom the Cardiology Branch, National Heart Institute, National Institutes of Health, Bethesda, Maryland.Presented in part before the American College of Physicians, Denver, Colorado, April 2, 1963.Requests for reprints should be addressed to Eugene Braunwald, M.D., Cardiology Branch, National Heart Institute, National Institutes of Health, Bethesda 14, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDonald Carey Harrison, MD: A Conversation With the Editor⁎⁎This series of interviews was underwritten by an unrestricted grant from Bristol-Myers Squibb.The Use of Inotropic Agents in Acute and Chronic Congestive Heart FailureClinical Features of Adrenergic Agonists and AntagonistsInotropic drugs in acute circulatory failureDobutamine: A New Synthetic Cardioactive Sympathetic AmineThe Transport of Biogenic AminesShock in myocardial infarction—Medical treatmentHemodynamic measurements in a coronary care unitNature of intraventricular pressure differences induced by pharmacological agents in dogsThe treatment of shock complicating acute myocardial infarctionHemodynamic Studies in Cardiogenic ShockFalse Neurochemical Transmitters Combined Clinical Staff Conference at the National Institutes of HealthROBERT A. COHEN, M.D., IRWIN J. KOPIN, M.D., CYRUS R. CREVELING, PH.D., JOSE M. MUSACCHIO, M.D., JOSEF E. FISCHER, M.D., J. RICHARD CROUT, M.D., JOHN R. GILL JR., M.D.Inhibitors of monoamine oxidase and decarboxylase of aromatic amino acidsEffect of vasopressor drugs on circulatory dynamics in shock following myocardial infarctionMechanisms of pressor amine dependencePresence of α-Methyl-noradrenaline ('Corbasil') in the Heart of Guinea-pigs Treated with Metaraminol ('Aramine')SYMPATHOMIMETIC DRUGSModification of the hypertensive effect of metaraminolRelease of Metaraminol (Aramine) from the Heart by Sympathetic Nerve StimulationNewer Agents in the Treatment of Shock 1 September 1963Volume 59, Issue 3Page: 297-305KeywordsHeartHemodynamicsLongitudinal studiesNeurotransmittersNorepinephrine ePublished: 1 December 2008 Issue Published: 1 September 1963 PDF downloadLoading ...