Palladium(II)‐Catalyzed Intramolecular Diamination of Alkynes under Aerobic Oxidative Conditions: Catalytic Turnover of an Iodide Ion

“I” did it: A sequential intramolecular amination/N-demethylation/amidation of internal acetylenes in the presence of a catalytic amount of Pd(OAc)2 and nBu4NI afforded indolo[3,2-c]isoquinolinones under mild aerobic conditions (see scheme, DMSO=dimethyl sulfoxide). The iodide ion was regenerated by reaction of in situ generated MeI with HOAc present in the reaction mixture.