Why the study?
Severe AR demonstrates excess long-term morbidity and mortality, necessitating consideration of early surgical or transcatheter treatment in high-risk patients.
Highlights the need for considering early surgical or transcatheter treatment in high-risk patients with severe aortic regurgitation due to excess morbidity and mortality.
Severe AR carries excess long-term morbidity and mortality; leaves optimal intervention timing open in asymptomatic patients.
Aortic insufficiency/regurgitation in the native valve can result due to various congenital and acquired anomalies, leading to abnormalities of the aortic valve leaflets, their supporting structures (aortic root and annulus), or both. Aortic regurgitation (AR) also may be seen after surgical or catheter-based intervention on the aortic valve. Although chronic AR may develop in a slow and insidious manner, long-term follow-up of patients with severe AR has demonstrated excess morbidity and mortality, necessitating consideration of early surgical or transcatheter treatment in high-risk patients. Abbreviations AR: aortic regurgitation; AS: aortic stenosis; BAV: bicuspid aortic valve; LBBB: left bundle branch block; LV: left ventricle; LVEF: left ventricular ejection fraction; LVESD: left ventricular end-systolic dimension; MAVD: mixed aortic valve disease; NAVR: native aortic valve regurgitation; PAS: pure aortic stenosis; PPM: permanent pacemaker; PVR: prosthetic valve regurgitation; SAVR: surgical aortic valve replacement; SVD: structural valve deterioration; TAVR: transcatheter aortic valve replacement; VIV: valve in valve
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Siddique et al. (2020) studied this question.
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