Low frequency of BMPR2 mutations in a German cohort of patients with sporadic idiopathic pulmonary arterial hypertension

RT-PCR products were obtained using region specific Key points N Idiopathic pulmonary arterial hypertension (IPAH) is a rare progressive disorder in which elevated pulmonary artery pressure, in the absence of secondary causes, leads to right heart failure and death. Mutations of the bone morphogenetic protein receptor type II gene (BMPR2) have been identified in both familial and sporadic cases.