Why the study?
Are PON1, P2Y12, and COX1 polymorphisms associated with increased risk of recurrent ischemic events in patients with extracranial or intracranial stenting on dual antiplatelet therapy?
Population
268 patients with symptomatic extracranial or intracranial stenosis scheduled for stenting and receiving…
Comparison
Presence of PON1 rs662 allele C, P2Y12 rs2046934… vs Absence of these genetic variants
Design
Cohort
Follow-up
12 months
Authors
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These associations should not change DAPT practice after stenting; hypothesis-generating for genetic risk stratification.
Are PON1, P2Y12, and COX1 polymorphisms associated with increased risk of recurrent ischemic events in patients with extracranial or intracranial stenting on dual antiplatelet therapy?
Genetic polymorphisms in PON1, P2Y12, and COX1 are associated with an increased risk of recurrent ischemic events in patients undergoing extracranial or intracranial stenting on dual antiplatelet therapy.
Li et al. (2016) studied this question.
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