Why the study?
Does ibuprofen prevent depressed cardiac function during aortic clamping in patients undergoing abdominal aortic aneurysmectomy?
Population
26 patients undergoing abdominal aortic aneurysmectomy (AAA)
Comparison
Ibuprofen 12 mg/kg by mouth 1.5 hours prior to… vs Placebo by mouth 1.5 hours prior to surgery
Design
Other, blinded fashion
Follow-up
During surgery (up to 30 minutes after aortic clamping)
Authors
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May support ibuprofen with volume loading to preserve cardiac index during aortic clamping; hypothesis-generating and requires randomized confirmation.
Does ibuprofen prevent depressed cardiac function during aortic clamping in patients undergoing abdominal aortic aneurysmectomy?
Preoperative administration of ibuprofen combined with adequate volume loading (PAWP ≥ 10 mmHg) prevents the decline in cardiac index during aortic clamping in abdominal aortic aneurysmectomy.
HUVAL et al. (1984) studied this question.
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