Interaction of Twenty-Seven Bicyclo Derivatives with VEGF Receptors as a Therapeutic Alternative to Treat Cancer

Several studies indicate that cancer development is associated with angiogenesis, which may be conditioned for VEGFR-1, VEGFR-2, and VEGFR-3 expression. It is noteworthy that some drugs, such as axitinib, cediranib, regorafenib, and sorafenib, have been used to treat cancer. Nevertheless, some of these drugs can induce different adverse effects, such as thrombocytopenia and leukopenia. Analyzing these data, this study aimed to evaluate whether bicyclo analogs (1-27) could couple with VEGFR-1, VE