Research Progress of Ferroptosis in Acute Kidney Injury

Acute kidney injury (AKI) is an acute disease with high incidence and mortality. It is characterized by rapid deterioration of renal function and further accumulation of metabolic waste and toxins, leading to complications and dysfunction in other organs. Multiple pathogenic factors, such as rhabdomyolysis, infection, nephrotoxic drugs, and ischemia-reperfusion injury, contribute to the development and development of AKI. However, the specific mechanism is still unclear. Ferroptosis is a non-apoptotic cell death mechanism that is iron-dependent and is thought to be a process of iron accumulation and enhanced lipid peroxidation. Various studies suggest that ferroptosis plays an important role in the development of AKI. This review summarizes the potential role of ferroptosis in the pathogenesis and treatment of acute kidney injury.