Why the study?
Is there an increased frequency of anti-alpha-enolase antibodies in mothers of children with congenital heart block compared to SLE patients and healthy controls?
Is there an increased frequency of anti-alpha-enolase antibodies in mothers of children with congenital heart block compared to SLE patients and healthy controls?
The low frequency of anti-alpha-enolase antibodies in CHB mothers suggests that antibodies to Ro52 are unlikely to mediate congenital heart block via binding to alpha-enolase.
No takes yet. Share an insight, caveat, or question.
Should not guide anti-alpha-enolase testing in CHB risk assessment; leaves open Ro52 antibody mechanisms for investigation.
Llanos et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: