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February 1, 1975Proceedings of the National Academy of SciencesOpen Access

The in vitro addition of a polyadenylate sequence to the 3' end of phage Qbeta RNA and the biological activity of the product.

Charles Gilvarg F.J. Bollum C. Weissmann

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Abstract

Terminal riboadenylate transferase, purified from calf thymus, has been used to add a poly(A) extension to the 3' end of Qbeta RNA. The modified Qbeta RNA retains full infectivity in a spheroplast assay system. However, the progeny viruses do not contain poly(A) termini, indicating an in vivo rectification of the in vitro alteration.

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Gilvarg et al. (1975) studied this question.

synapsesocial.com/papers/6a7d3cdd1ec2a9317b425789 https://doi.org/10.1073/pnas.72.2.428

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