Why the study?
High exercise volumes may have deleterious cardiovascular effects, and the upper thresholds for safe exercise volumes remain unclear.
Do high exercise volumes influence the coronary artery disease profile by coronary CTA and cardiovascular outcomes in patients undergoing coronary CTA?
Do high exercise volumes influence the coronary artery disease profile by coronary CTA and cardiovascular outcomes in patients undergoing coronary CTA?
High exercise levels up to 9 hours per week appear safe and do not have a deleterious impact on the coronary atherosclerosis profile as assessed by CTA.
Supports safety of high exercise volumes on CTA plaque; leaves open prospective outcome confirmation.
Background: High exercise volumes may have deleterious effects on the cardiovascular system, and the upper thresholds for "safe" volumes are unclear. Objective: To evaluate if high-exercise volumes influence the coronary artery disease (CAD) profile by coronary CTA, cardiovascular outcomes, compared with traditional CVRF. Methods: 802 patients (age 57.6 ± 10.95 years;38.1 % women) undergoing coronary CTA were enrolled. Self-reported exercise habits were collected: Type, volume (frequency/week and time/per unit); and years of training. Endpoints were: CTA: coronary stenosis severity (CADRADS); high-risk-plaque (HRP); coronary artery calcium score (CAC), and MACE. Results: = 0.231; OR 1.58 (95 % CI: 0.787-3.222) and smoking was more prevalent in controls. There was no difference in HRP after adjusting for all CVRF. MET was mean 8.78 ± 3.5; weekly training volume 9 h. The majority (78 %) reported >5 -10 years of training. Conclusion: High-exercise levels (up to 9h/week) are safe - without a deleterious impact on the coronary atherosclerosis profile.
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Feuchtner et al. (2025) studied this question.
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