The Effect of a Continuous Intravenous Infusion of Inorganic Phosphate on the Rachitic Lesions in Cystinosis

reported healing of rachitic lesions in vitamin D-deficient and in hypophosphataemic refractory rickets by intravenous administration of phosphate. The concentration of serum inorganic phosphorus, which initially had been very low, was kept at normal levels for a period of five to seven days. The authors concluded that vitamin D was not obligatory for healing in these types of rickets. The metabolic defect in cystinosis leading to severe amino-aciduria, glycosuria, metabolic acidosis and deposition of cystine crystals in various organs, in addition to hypophosphataemia and rickets, is undoubtedly more severe than in infantile and primary refractory rickets. But there is no valid reason to suppose that the pathogenesis of rachitic