Pulmonary Toxicity of Isocyanates

Editorial Notes1 October 1970Pulmonary Toxicity of IsocyanatesJOHN M. PETERS, M.D., RAYMOND L. H. MURPHY, M.D.JOHN M. PETERS, M.D., RAYMOND L. H. MURPHY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-4-654 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn our plastic world polyurethanes have achieved great commercial importance. The production of polyurethane involves the combination of chemicals containing two highly reactive isocyanate groups with a polyol. It is during this mixing and foaming process that the isocyanates are evolved into the workroom atmosphere. Depending on plant configuration and ventilation, few or many workers can be exposed. Other significant exposures may occur in industrial chemical laboratories and during repair or cleaning of the equipment. The products are used primarily as cushioning materials (mattresses, pillows, seat cushions, and packing materials), for insulation (thin-walled refrigerators and ovens), for soft toys, and...References1. FUCHSVALADE SP: Étude clinique et expérimentale sur quelques cas d'intoxication par le Desmodur T (Diisocyanate de Toluylene 1-2-4 et 1-2-6). Arch Mal Prof 12:191-196, 1951 MedlineGoogle Scholar2. BRUGSCHELKINS HH: Toulene di-isocyanate (TDI) toxicity. New Eng J Med 268:353-357, 1963 CrossrefMedlineGoogle Scholar3. SCHEELKILLENSJOSEPHSON LRA: Immonchemical aspects of toluene diisocyanate (TDI) toxicity. Amer Industr Hyg Ass J 25:179-184, 1964 CrossrefMedlineGoogle Scholar4. AVERYSTETSONPAN ADP: Immunological investigation of individuals with toluene diisocyanate asthma. Clin Exp Immun 4:585-596, 1969 MedlineGoogle Scholar5. TAYLOR G: Immune responses of tolylene diisocyanate (TDI) exposure in man. Proc Roy Soc Med 63:379-380, 1970 CrossrefMedlineGoogle Scholar6. GANDEVIA B: Studies of ventilatory capacity and histamine response during exposure to isocyanate vapour in polyurethane foam manufacture. Brit J Industr Med 20:204-209, 1963 MedlineGoogle Scholar7. PETERSMURPHYPAGNOTTO JRL: Acute respiratory effects in workers exposed to low levels of toluene diisocyanate (TDI). Arch Environ Health (Chicago) 16:642-647, 1968 CrossrefMedlineGoogle Scholar8. MCKERROWDAVIESJONES CHA: Symptoms and lung functions following acute and chronic exposure to tolylene diisocyanate. Proc Roy Soc Med 63:376-378, 1970 CrossrefMedlineGoogle Scholar9. HILL R: A controlled study of workers handling organic diisocyanates. Ibid., p. 375 Google Scholar10. ADAMS W: Lung function of men engaged on the manufacture of tolylene diisocyanate (TDI). Ibid., pp. 378-379 Google Scholar11. PETERS J: Cumulative pulmonary effects in workers exposed to tolylene diisocyanate. Ibid., pp. 372-375 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN M. PETERS, M.D.; RAYMOND L. H. MURPHY, M.D.Affiliations: The Kresge Center for Environmental Health Harvard School of Public Health Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNitrogen‐Containing Polymers Derived from Terpenes: Possibilities and LimitationsCellulose nanocrystals from agricultural resources: Extraction and functionalisation(+)-Limonene Functionalization: Syntheses, Optimization, and Scale-up Procedures for Sustainable Polymer Building BlocksProcess investigating and modelling for the self-polymerization of toluene diisocyanate (TDI)-based polyurethane prepolymerMethods for Estimating the Transfer Efficiency of a Compressed Air Spray GunIsocyanatesShort-term respiratory changes in polyurethane foam workers exposed to low MDI concentrationPersistent reactive airway dysfunction syndrome after exposure to toluene diisocyanate.Isocyanates and respiratory disease: Current statusUse of repeated co 2 challenges to evaluate the pulmonary performance of guinea pigs exposed to toluene diisocyanateSentinel Health Events (Occupational): A Basis for Physician Recognition and Public Health SurveillanceSentinel Health Events (occupational): a basis for physician recognition and public health surveillance.Response of the lung to inhaled antigensKlinik und Pathologie der DiisocyanatvergiftungenEnvironmental Lung Disease 1 October 1970Volume 73, Issue 4Page: 654-655KeywordsToxicity ePublished: 1 December 2008 Issue Published: 1 October 1970 PDF downloadLoading ...