Spx-RNA Polymerase Interaction and Global Transcriptional Control during Oxidative Stress

Spx is a unique RNA polymerase (RNAP)-binding protein that is highly conserved among low-G+C-content gram-positive bacteria and certain members of the Mollicutes . In the spore-forming bacterium Bacillus subtilis , its primary target is the C-terminal domain (CTD) of the RNAP α subunit (αCTD) ([43