Why the study?
To enhance understanding of cardiac function in physiological and pathological conditions using mathematical and numerical modeling, addressing challenges from its multi-scale and multi-physics nature.
Population
Patient-specific biventricle geometry
Comparison
Different fibre directions and bulk modulus variations
Design
Mathematical and numerical modeling simulation study
Authors
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Simulations of ventricular function are sensitive to fiber parameters; leaves open their incorporation into patient-specific models.
Computational electromechanical modeling demonstrates that fiber orientation and bulk modulus significantly impact simulated clinical parameters like stroke volume and ejection fraction.
Azzolin et al. (2020) studied this question.