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June 1, 1994Angiology

Following IV rt-PA administration, the patient developed a new occlusion of the left intracranial internal carotid artery and a branch of the left external artery, with echocardiography revealing a mobile thrombus in the left ventricle.

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Why the study?

Does intravenous rt-PA cause recurrent embolization in patients with acute cardioembolic stroke and intracardiac mobile thrombi?

Population

n=1, 45-year-old man with dilated cardiomyopathy and acute cardioembolic stroke.

Design

Case_report

Follow-up

just after treatment

Authors

MYMasahiro YasakaTYTakenori YamaguchiTYToshiro Yonehara

Discussion

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Overview

IV rt-PA may be associated with recurrent embolization from mobile LV thrombus; this case report leaves the risk open for further study.

Structured PICO

Does intravenous rt-PA cause recurrent embolization in patients with acute cardioembolic stroke and intracardiac mobile thrombi?

P
Population
n=1, 45-year-old man with dilated cardiomyopathy and acute cardioembolic stroke (left middle cerebral artery trunk occlusion).
I
Intervention
Intravenous administration of 30 megaunits (MU) of recombinant tissue plasminogen activator (rt-PA) over 60 minutes, commenced 2 hours after ictus.
O
Outcome
Recurrent embolization (new occlusion of the left intracranial internal carotid artery and a branch of the left external artery)safety

Intravenous rt-PA in acute cardioembolic stroke may accelerate the breakup or detachment of intracardiac mobile thrombi, leading to recurrent embolization.

Cite This Study

Yasaka et al. (1994) studied this question.

synapsesocial.com/papers/6a7d5210c7e6f6a50737d481https://doi.org/10.1177/000331979404500611
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