Why the study?
Do antihypertensive drugs (atenolol, captopril, losartan) alter specific harmonic indices of the pulse waveform in normotensive Wistar Kyoto rats?
Do antihypertensive drugs (atenolol, captopril, losartan) alter specific harmonic indices of the pulse waveform in normotensive Wistar Kyoto rats?
Harmonic analysis of the pressure pulse in a rat model reflects changes seen in humans, confirming it as a useful method to study the efficacy of antihypertensive drugs.
Differential harmonic effects may distinguish beta-blocker from ARB/ACEI actions in rats; leaves open translation to human antihypertensive selection.
We used a self-comparison method and harmonic analysis to compare the blood pressure wave before and after the injection of antihypertensive drugs (atenolol, captopril, and losartan) in normotensive Wistar Kyoto rats. Systolic and diastolic blood pressures decreased significantly after the intraperitoneal injection of drugs. Atenolol significantly reduced all the harmonic proportions of the pulse wave, while captopril and losartan significantly increased the first and fourth harmonic proportions. These findings are the same as those reported for human subjects and confirm that harmonic analysis of the pressure pulse is a useful method to study the efficacy of antihypertensive drugs.
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Wang et al. (2011) studied this question.
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