Why the study?
Interhospital transfer of STEMI patients undergoing primary PCI can increase ischemic time compared to direct admission, but its impact on time to reperfusion and one-year mortality needed assessment.
Does interhospital transfer increase time to reperfusion and one-year mortality compared to direct admission in patients with STEMI undergoing primary PCI?
Does interhospital transfer increase time to reperfusion and one-year mortality compared to direct admission in patients with STEMI undergoing primary PCI?
Although interhospital transfer for STEMI significantly increases ischemic time, it may not adversely impact one-year mortality compared to direct admission, potentially due to higher baseline clinical severity (e.g., Killip class IV) among direct presenters.
No mortality difference despite longer delays in this cohort; leaves open whether transfer protocols affect STEMI outcomes.
In a primary percutaneous coronary intervention (PCI) program, interhospital transfer of patients with ST-elevation myocardial infarction (STEMI) can increase ischemic time, compared to patients who are admitted directly to a catheterization laboratory. To assess the impact of interhospital transfer in patients with STEMI undergoing primary PCI, in terms of time to reperfusion and one-year mortality. This was an observational, retrospective, longitudinal study of patients with STEMI admitted to Hospital de Braga between June 2011 and May 2016, who were treated successfully within 12 hours of symptom onset. A total of 1222 patients were included and divided into two groups according to admission to Hospital de Braga: direct or interhospital transfer. In this study, 37.0% (n=452) of the population were admitted directly to Hospital de Braga and 63.0% (n=770) were transferred from other hospitals. Although timings (in min) until reperfusion were longer in interhospital transfer patients (symptom onset-first medical contact (median 76.5, IQR 40.3–150 vs. 91.0, IQR 50–180, p=0.002), first medical contact-reperfusion (median 87.5, IQR 69.0–114 vs. 145, IQR 115–199, p<0.001) and symptom onset-reperfusion (median 177, IQR 125–265 vs. 265, IQR 188–400, p<0.001)), one-year mortality did not differ significantly between the groups (53 [11.7 %] vs. 71 [9.2 %], p=0.193). In multivariate analysis, age, symptom onset-reperfusion time and especially Killip class IV at admission (HR 11.2, 95 % CI 6.35–19.8, p<0.001) were the main independent predictors of one-year mortality. Interhospital transfer of patients with STEMI increased the time before PCI. No differences were detected between groups in one-year mortality. This may be related to the fact that the direct admission group had twice as many patients in Killip class IV as the interhospital transfer group. Num programa de angioplastia primária, a transferência inter-hospitalar dos doentes com enfarte agudo do miocárdio com elevação do segmento ST (EAMcEST) pode aumentar o tempo de isquemia relativamente aos doentes que são admitidos diretamente num laboratório de hemodinâmica. Avaliar o impacto da transferência inter-hospitalar nos doentes submetidos a intervenção coronária percutânea primária (ICPp), no intervalo de tempo até à reperfusão e na mortalidade a um ano. Estudo observacional, retrospetivo e longitudinal. 1222 doentes com EAMcEST admitidos no Hospital de Braga (HB), entre junho/2011 e maio/2016, tratados com sucesso nas primeiras 12 horas de evolução dos sintomas, foram divididos em dois grupos consoante a admissão: direta ou transferência inter-hospitalar. 37.0 %(n=452) foram admitidos diretamente no HB e 63.0 %(n=770) transferidos de outros hospitais. Apesar do aumento nos intervalos de tempo (em minutos) até à reperfusão nos doentes da transferência inter-hospitalar (início dos sintomas-primeiro contato médico) (Mdn = 76,5,AIQ (40,3–150) versus Mdn = 91,0,AIQ (50–180), p=0002), primeiro contato médico-reperfusão (Mdn = 87,5, AIQ (69,0–114) versus Mdn = 145, AIQ (115–199),p<0001) e início dos sintomas-reperfusão (Mdn = 177,AIQ(125–265) versus Mdn = 265, AIQ (188–400),p<o,001)), a mortalidade a um ano não diferiu significativamente entre os grupos (53(11.7 %)versus 71(9.2 %), p=0193). Na análise multivariada, a idade, o tempo sintomas-reperfusão e sobretudo a classe Killip IV à admissão (HR = 11,2, IC95 % [6,35–19,8], p<0001) revelaram-se os principais preditores independentes de mortalidade a um ano. A transferência inter-hospitalar dos doentes com EAMcEST aumentou de forma significativa o intervalo de tempo até à realização da ICPp. Relativamente à mortalidade a um ano, não se detetaram diferenças entre grupos. Isto pode estar relacionado com o fato de o grupo da admissão direta ter o dobro de doentes em Killip IV.
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Ferreira et al. (2019) studied this question.
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