Puffer-fish poison and clam poison reversibly inhibit conduction in single nerve fiber preparation of frog in a concentration of 3 x 10-10 M. In the isolated electroplax of Electrophorus electricus higher concentrations block both transmission and conduction. Neither toxin is a potent acetylcholinesterase inhibitor. The mechanism of action of these toxins in blocking transmission and conduction has not yet been established.
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Meyer et al. (1960) studied this question.
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