Key result
Higher serum adiponectin is linked to ~48% lower coronary heart disease risk.
Why the study?
The association of serum adiponectin concentrations with coronary heart disease risk and its correlation with cardiovascular risk markers required investigation after adjustment for established risk factors.
Is higher serum adiponectin associated with a lower risk of coronary heart disease?
Case-Control (n=788)
Is higher serum adiponectin associated with a lower risk of coronary heart disease?
Odds Ratio: 0.52 (95% CI 0.28–0.95)
p-value: p=<0.007
Higher serum adiponectin concentrations are associated with a lower risk of stable coronary heart disease, an effect that may be partly mediated by HDL metabolism.
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Higher adiponectin linked to lower CHD odds largely via HDL; leaves open independent predictive role or measurement in practice.
Rothenbacher et al. (2005) conducted a case-control in Coronary heart disease (n=788). Serum adiponectin concentrations vs. Lower quintile of serum adiponectin concentrations was evaluated on Coronary heart disease (CHD) (OR 0.52, 95% CI 0.28-0.95, p=<0.007). Higher serum adiponectin concentrations (upper vs. lower quintile) were associated with a reduced risk of coronary heart disease (OR 0.52; 95% CI 0.28-0.95; P<0.007 for trend).
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