A highly efficient procedure for the phosphorylation of sugar hydroxy derivatives has been developed. A four-step sequence comprising H-phosphonate formation, pivaloyl chloride-mediated coupling with fluoren-9-ylmethanol, oxidation, and cleavage of the fluoren-9-ylmethyl ester led to the sugar monophosphate derivatives 4a–g in 83–93% yield.
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Yashunsky et al. (2000) studied this question.
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