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December 1, 2009OMICS A Journal of Integrative BiologyOpen Access

CHF1/Hey2 Promotes Physiological Hypertrophy in Response to Pressure Overload through Selective Repression and Activation of Specific Transcriptional Pathways

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Why the study?

Does CHF1/Hey2 overexpression prevent pathological hypertrophy and apoptosis in response to pressure overload in mice?

Population

Wild-type and transgenic mice overexpressing CHF1/Hey2 in the myocardium, and cultured neonatal myocytes…

Comparison

Ascending aortic banding and exposure to… vs Wild-type mice and sham-operated controls.

Design

Preclinical

Follow-up

1 week

Authors

MYMan YuHospital for Sick ChildrenYLYonggang LiuSouthwest University of Science and TechnologyYLYuxin LiHeilongjiang University of Chinese Medicine

Discussion

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Implication

Does not inform clinical practice; leaves open CHF1/Hey2 as a therapeutic target in human pressure-overload HF.

Structured PICO

Does CHF1/Hey2 overexpression prevent pathological hypertrophy and apoptosis in response to pressure overload in mice?

P
Population
Wild-type and transgenic mice overexpressing CHF1/Hey2 in the myocardium, and cultured neonatal myocytes from these animals.
I
Intervention
Ascending aortic banding (pressure overload) and exposure to hydrogen peroxide (in vitro).
C
Comparator
Wild-type mice (for transgenic comparison) and sham-operated controls.
O
Outcome
Development of cardiac hypertrophy (ventricular weight to body weight ratios), fractional shortening, fibrosis, and apoptosis.surrogate

CHF1/Hey2 promotes physiological over pathological hypertrophy in response to pressure overload by suppressing apoptosis and regulating transcriptional pathways, suggesting a potential target for heart failure drug discovery.

Cite This Study

Yu et al. (2009) studied this question.

synapsesocial.com/papers/6a7d64111e40f448689665echttps://doi.org/10.1089/omi.2009.0086
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy2001 · 120 citations
  2. 2Protein kinase cascades in the regulation of cardiac hypertrophy2005 · 615 citations
  3. 3The Fuzzy Logic of Physiological Cardiac Hypertrophy2007 · 334 citations
  4. 4Transcription Factor CHF1/Hey2 Regulates Neointimal Formation In Vivo and Vascular Smooth Muscle Proliferation and Migration In Vitro2004 · 92 citations
  5. 5Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function2007 · 119 citations