Cartilage anomaly (can); a new mutant gene in the mouse

Cartilage anomaly (symbol can) is a recessive gene in the mouse producing achondroplasia. Abnormal mice die at about 10 days after birth. Light microscopy reveals a systemic deficiency in the cartilaginous matrix. Electron microscopy suggests that the collagen of the matrix is normal and that the mucopolysaccharide component is reduced.