Variations in kidney area were measured on X-ray films following the injection of contrast medium and urea. A mean increase of 7·8 per cent following contrast-medium injection was demonstrated in hypertensive patients with normal renal arteries. In normotensive patients the mean increase was 4·8 per cent. Additional infusion of urea (washout urography) in the hypertensive group produced a further increase in renal area to an average maximum of 11·4 per cent. A rise in interstitial pressure associated with intrarenal vasodilatation is a possible explanation. The response has physiological and clinical implications.
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Dorph et al. (1973) studied this question.
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