The hydroxyproline, and hence collagen, content of epiphysial cartilage from rats treated with AAN is not reduced from the normal. Homogenized fractions of cartilage from rats which have received AAN are virtually devoid of collagen fibrils when examined with electron microscope. The defect appears to be a failure of the tropocollagen molecule to form collagen fibers.
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Follis et al. (1958) studied this question.